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Health effects of combustion generated ultrafine particles (UFP): How UFP can enter the human organism – size matters
Combustion derived nanoparticles, i.e. particles of a size of ≤200-300 nm, behave differently compared to micron-sized particles physicochemically and, in particular, when interacting with biological systems.
Nanoparticles mainly enter our organism may by inhalation, i.e. through the respiratory tract. The intact skin is a good barrier against nanoparticles. Most of the nanoparticles entering via oral way will pass through the gastro-intestinal tract where they may enter the tissue, mainly in the small intestines.
In the lungs, which they enter deeply, i.e. until the alveolar or gas-exchange region, deposited nanoparticles, unlike micron-sized particles, may penetrate through the air-blood tissue barrier and enter the pulmonary vascular circulation. These nanoparticles will translocate into all organs, but in different amounts. It is not clear yet, by which mechanisms they enter and leave the blood stream and what their effect is in the different organs. These are questions under extensive investigation worldwide. However, it is a fact that the smaller they are the more can be detected in the different organs.
The talk will present the lung as the main portal of entry for nanoparticles. It will explain and discuss the fate of inhaled combustion generated nanoparticles including possible mechanisms of entering cells and tissue, and it will finally discuss possible health effects.
Nanoparticles mainly enter our organism may by inhalation, i.e. through the respiratory tract. The intact skin is a good barrier against nanoparticles. Most of the nanoparticles entering via oral way will pass through the gastro-intestinal tract where they may enter the tissue, mainly in the small intestines.
In the lungs, which they enter deeply, i.e. until the alveolar or gas-exchange region, deposited nanoparticles, unlike micron-sized particles, may penetrate through the air-blood tissue barrier and enter the pulmonary vascular circulation. These nanoparticles will translocate into all organs, but in different amounts. It is not clear yet, by which mechanisms they enter and leave the blood stream and what their effect is in the different organs. These are questions under extensive investigation worldwide. However, it is a fact that the smaller they are the more can be detected in the different organs.
The talk will present the lung as the main portal of entry for nanoparticles. It will explain and discuss the fate of inhaled combustion generated nanoparticles including possible mechanisms of entering cells and tissue, and it will finally discuss possible health effects.
Tematyka artykułu: Osprzęt silników
Autor: Peter Gehr
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